Polygenic risk scores

Abstract

Topics: polygenic model of complex traits and disease susceptibility; discovery (training), validation and target (test) samples; calculation of PRS – p-value informed clumping and thresholding; evaluation (performance metrics – variance explained, odds ratio, AUC, precision-recall curve) and interpretation; software and implementation; application in clinical settings; translational potential of PRS; introduction to advanced polygenic modeling

Date
Location
Boston, MA

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Amanda Blue Zheutlin
Postdoctoral Fellow